By K. Thapar, K. Kovacs, E. R. Laws (auth.), L. Symon, L. Calliauw, F. Cohadon, V. V. Dolenc, J. Lobo Antunes, H. Nornes, J. D. Pickard, H.-J. Reulen, A. J. Strong, N. de Tribolet (eds.)
As an addition to the ecu postgraduate education process for younger neurosurgeons we started to submit in 1974 this sequence of Advances and Technical criteria in Neurosurgery which used to be later subsidized via the eu organization of Neurosurgical Societies. This sequence was once fust mentioned in 1972 at a mixed assembly of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the sequence being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbUhl. therefore have been confirmed the rules of ecu co operation that have been born from the eu spirit, flourished within the ecu organization, and feature all through been linked to this sequence. the truth that the English language is definitely which will changing into the foreign medium at eu medical meetings is a brilliant asset by way of mutual realizing. consequently now we have determined to submit all contributions in English, whatever the local language of the authors. All contributions are submitted to the total editorial board earlier than publi cation of any quantity. Our sequence isn't really meant to compete with the courses of unique clinical papers in different neurosurgical journals. Our goal is, fairly, to provide fields of neurosurgery and comparable parts within which very important fresh advances were made. The contributions are written by way of experts within the given fields and represent the fust a part of every one volume.
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By definition, such tumors are designated as "null cell adenomas". Adenomas of this class may exist as one of two variants: the pure null cell adenomas and the oncocytomas. The distinction is purely a morphological one and relates to the intracellular accumulation of dilated mitochondria in oncocytomas. Thus, oncocytomas are simply null cell adenomas in which the intracellular mitochondrial content exceeds 10 per cent of the cell volume. This single morphologic distinction aside, null cell adenomas and their oncocytic variants can be considered biologically equivalent tumors, for neither clinical nor prognostic differences exist between the two.
Extracranial spread of pituitary carcinomas involves both hematogenous and lymphatic routes. Invasion of the cavernous sinus provides the necessary venous access for transport to the internal jugular vein via the petrosal system. Although the pituitary itself lacks lymphatic drainage, invasion of the tumor into the skull base provides access to a rich lymphatiG network, one which in tum mediates systemic dissemination. Death from pituitary carcinoma is invariably the result of mass effects from extensive intracranial disease.
1986). The incorporated BrDU in tumor tissue is revealed by immunohistochemistry using antiBrDU antibody. 5 per cent. The consistent finding that tumors of Nelson's syndrome have the highest S-phase fractions validates the aggressiveness observed clinically in this group of tumors. The narrow range of observed S-phase fractions in pituitary adenomas overall, however, limits the sensitivity of this technique in distinguishing subtle differences in S-phase fractions between aggressive and non-aggressive pituitary adenoma variants.