A History of Immunology, Second Edition by Arthur M. Silverstein

By Arthur M. Silverstein

Written through an immunologist, A background of Immunology traces the idea that of immunity from precedent days as much as the current day, analyzing how altering recommendations and applied sciences have affected the process the technological know-how. It exhibits how the personalities of scientists or even political and social components motivated either concept and perform within the box. With interesting tales of medical disputes and transferring clinical traits, each one bankruptcy examines a huge aspect of this self-discipline that has been so principal to the advance of recent biomedicine. With its biographical dictionary of significant scientists and its lists of important discoveries and books, this quantity will give you the such a lot entire historic reference within the field.

  • Written in a sublime variety by way of long-time working towards immunologist
  • Discusses the altering theories and applied sciences that guided the field
  • Tells of the fascinating disputes between well known scientists
  • Lists all of the very important discoveries and books within the field
  • Explains intimately the various Nobel prize-winning contributions of immunologists

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Extra info for A History of Immunology, Second Edition

Example text

This would not only lead to cessation of growth during the initial infection, but retention of these inhibitors in the host would also confer lasting immunity. The specificity of this immunity was explained by assuming that each species of pathogen produces substances peculiar to its own metabolism, and to whose inhibitory effect they alone are sensitive. 49 In studies of anthrax infection of Algerian sheep, Chauveau observed that the offspring of ewes infected during pregnancy, and especially shortly before parturition, showed an increased resistance to anthrax infection.

This was helped in no small measure by the pictures which Ehrlich published to illustrate his side-chain theory – pictures that made it easier to believe that antibodies and complement were ‘‘real substances’’ with comprehensible receptors and simple modes of action. By the turn of the century, then, it would appear safe to conclude that most active investigators favored one or another modification of a humoral theory to explain natural immunity and, certainly, acquired immunity. Metchnikoff was correct in receiving the impression at a congress in 1900 that his theory was not well understood, but was perhaps too late in his attempt to rectify this situation by publication a year later of his famous book Immunity in the Infectious 2 Cellular vs humoral immunity 37 Diseases.

Although the word virus continued to be applied nonspecifically to all pathogens for many years until its usage was restricted to the ultrafilterable and ultramicroscopic agents, and although it might even have retained its connotation as ‘‘poison’’ to some, the advances of the late nineteenth and early twentieth centuries largely demystified and even detoxified many diseases. Concepts such 1 Theories of acquired immunity 21 as those outlined above could not long survive the new knowledge derived from bacteriology, immunology, and experimental pathology.

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